Part of antiretroviral combination therapy for HIV patients.
Dosage/Direction for Use
Adult & adolescent >12 yr 150 mg bid or 300 mg once daily. Childn 3 mth to 12 yr 4 mg/kg bid up to max 300 mg daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity.
Special Precautions
Not for monotherapy use. Moderate to severe renal impairment. May cause high rate or urological failure & emergence of resistance at an early stage w/ tenofovir disoproxil fumarate & abacavir or didanosine. Opportunistic infections & other HIV complications. Pancreatitis, lactic acidosis, mitochondrial dysfunction, lipodystrophy, immune reactivation syndrome. Chronic hepatitis B or C, hepatomegaly or other known risk factors for liver disease & hepatic steatosis. Periodic monitoring of LFT & markers of HBV replication. Childn <3 mth. Pregnancy, lactation.
J05AF05 - lamivudine ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
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